Bis(2-chloroethyl)aminophosphoric Dichloride

Name	bis(2-chloroethyl)phosphoramidic dichloride
Synonyms	bis(2-chloroethyl)-dichlorophosphoryl-amine bis(2-chloroethyl)phosphoramidic dichloride Bis(2-chloroethyl)aminophosphoric Dichloride Bis(2-chloroethyl)aminophosphonic dichloride N,N-Bis(2-chloroethyl)phosphaMide Dichloride BIS-(2-CHLOROETHYL)AMINOPHOSPHONIC DICHLORIDE Phosphoramidic dichloride, bis(2-chloroethyl)- N,N-Bis(2-chloroethyl)phosphoraMidic Dichloride 2-chloro-N-(2-chloroethyl)-N-dichlorophosphorylethanamine 2-chloro-N-(2-chloroethyl)-N-dichlorophosphoryl-ethanamine
CAS	127-88-8
EINECS	683-015-0
InChI	InChI=1/C4H8Cl4NOP/c5-1-3-9(4-2-6)11(7,8)10/h1-4H2

Molecular Formula	C4H8Cl4NOP
Molar Mass	258.9
Density	1.509±0.06 g/cm3(Predicted)
Melting Point	54 °C
Boling Point	125 °C/0.7 mmHg
Flash Point	138.2°C
Solubility	Acetonitrile (Slightly), Benzene (Slightly), Chloroform (Slightly), DMSO (Slight
Vapor Presure	0.000847mmHg at 25°C
Appearance	Solid
Color	White to Pale Beige
pKa	-9.97±0.70(Predicted)
Storage Condition	Hygroscopic, Refrigerator, Under inert atmosphere
Refractive Index	1.501
Physical and Chemical Properties	Crystallization (ether). Melting point 54-56 ℃, boiling point 123-125 ℃/80Pa,110-114 ℃/13Pa, corrosive, sensitive to moisture, intense decomposition when heated.

chemical properties	crystallization (ether). Melting point 54-56 ℃, boiling point 123-125 ℃/80Pa,110-114 ℃/13Pa, corrosive, sensitive to moisture, intense decomposition when heated.
use	intermediate of cyclophosphamide.
Production method	Diethanolamine is chlorinated with thionyl chloride to generate N,N-bis (chloroethyl) amine hydrochloride, and then Condensation with phosphorus oxychloride to prepare the product.

Last Update：2024-04-10 22:29:15